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What are the side effects of long term use of proton pump inhibitors? Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B 12 deficiency, chronic kidney disease, and dementia.
Can I take PPI before bed? Patients are too often taking PPIs in the morning and not eating breakfast or taking their drug before bed on an empty stomach. A small adjustment in timing, or simply eating breakfast, may improve outcome. In patients with nighttime symptoms, an evening dose before dinner may be effective.
What medications should not be taken with antacids? Ask your doctor before taking antacids if you: Have kidney or liver problems. Are on a low-sodium diet. Are taking thyroid medication — such as Levoxyl or Synthroid (levothyroxine) — or the blood thinner Coumadin or Jantoven (warfarin), since antacids may interfere with these drugs.
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